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Document 2972
DOCN M94A2972
TI Site-specific relationship between oral spirochaetes and periodontal
disease in human immunodeficiency infection.
DT 9412
AU Wanzala P; Riviere G; Lukehart S; Kreiss J; DeRouen T; Ndinya A; Kenya
Medical Research Institute.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):182 (abstract no. PB0154). Unique
Identifier : AIDSLINE ICA10/94369603
AB OBJECTIVES: A Study of the distribution of Oral Spirochaetes in HIV
infected and uninfected individuals and their etiological significance
in periodontal disease. METHODS: 59 patients were included in the study.
Loss of attachment was measured at all the sites of teeth present,
Plaque samples from the 6 most affected sites and two least affected
sites in the individual. Pathogen-related oral spirochaetes were
investigated using monoclonal antibodies against pathogen specific
determinants on 47kDa and 37 kDa molecules. A questionnaire on the
patient's history and clinical status was also included. Blood was
collected for analysis for the presence of T. pallidum subsp pallidum.
RESULTS: A significant relationship was found between the site-specific
occurrence pathogen-related oral spirochaetes and sites with at least 4
mm loss of attachment (p < 0.01), with an odds ratio of 4.39 (95% CI =
(1.5-12.9)), and after adjusting for HIV infection the odds ratio was
7.6 (95% CI = (0.9-16.8)). CONCLUSION: The study provides a new
perspective into the etiological mechanisms of periodontal disease
especially in the HIV infected.
DE AIDS-Related Opportunistic Infections/*MICROBIOLOGY Dental
Plaque/MICROBIOLOGY Human Periodontal Index
Periodontitis/*MICROBIOLOGY Spirochaeta/ISOLATION & PURIF
Spirochaetales Infections/*MICROBIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).